Position: Associate Director of Biologics Production and Characterization

Reports To: Head of Protein Sciences, Generate Biomedicines

Location: Cambridge, MA (primary); Andover, MA (secondary)

The Company:

Generate Biomedicines, Inc. is a Flagship backed, privately-held biotechnology company on a mission to reimagine the drug discovery process to one of deterministic, data-driven generation. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. Generate will be successful by constantly turning innovative ideas into methods, technologies, and therapeutics that solve some of the most difficult challenges with developing medicines. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology.

The Role:

Generate is seeking an experienced, highly motivated, and innovative Associate Director of Biotherapeutics Production and Characterization to contribute to the development of our drug discovery platform and to drive delivery of our therapeutic pipeline.  She/he will be responsible for building and managing a team of scientists performing medium- and large-scale protein production using various host cell and cell-free systems across a range of different protein modalities supporting our growing portfolio of projects. The successful candidate will implement systems and strategies to deliver the highest quality protein and will provide leadership within project teams to facilitate project advancement and data feedback to our machine learning platform.  She/he will serve as a key point of contact with our Computational Sciences and our Preclinical Discovery and Development teams.  She/ he will also contribute to the building of our Process Development workflows and interface with CDMOs.

Responsibilities:

• Build and lead team of scientists and research associates across multiple sites performing protein expression, purification, and characterization
• Manage all protein production activities in group being accountable for planning, prioritization, and on-time delivery of generated protein variants
• Efficiently accomplish project goals on time and budget, tracking capacity constraints and resource use within team
• Stay scientifically current, and implement new technologies to enhance protein science capabilities with an emphasis on the machine learning data feedback loop
• Make intellectual contributions of the biotherapeutics production team to all stages of the drug discovery process and clearly articulate deliverables, progress, and issues to drug discovery teams
• Advise the leadership team on staff and resource needs, organizational planning, technology development, and other aspects as Generate continues to grow.
• Manage external CROs
• Contribute to Process Development and CMC activities at Generate, interfacing with internal PD/CMC team and CDMOs
• Potential for project leadership opportunities

Leadership: 

• Demonstrated ability to work across functions, regions, and cultures
• Functional level leadership with the ability to inspire, motivate and drive results
• Embraces and demonstrates a diversity and inclusion mindset and role models these behaviors for the organization
• Invests time in helping others to enhance their skills and perform at a higher level, including the skill and career development of direct reports

Required Skills/Experience:

• PhD or MS in science-related discipline
• Minimum of 8 years PhD/ 12yrs MS of biologics production experience in a biotech/pharma setting
• Evidence of creativity in addressing challenging protein production challenges
• 3+ years of management experience for Associate Director and 5+ years experience for Director
• Track record of successful leadership, management, and development of multi-disciplinary teams. Strong judge of talent with the ability to make tough talent decisions.
• Excellent communication, attention to detail, documentation and technical writing skills
• Familiarity of regulatory issues pertaining to the manufacture of biologics