Director of Protein Analytics

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The Company:

Generate Biomedicines, Inc. is a Flagship backed, privately-held biotechnology company on a mission to reimagine the drug discovery process to one of deterministic, data-driven generation. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. Generate will be successful by constantly turning innovative ideas into methods, technologies, and therapeutics that solve some of the most difficult challenges with developing medicines. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology.

The Role:

Generate is seeking an experienced and innovative Associate Director of Protein Analytics to join our growing team.  She/he will contribute to the development of our drug discovery platform and to the advancement of our therapeutic pipeline. Reporting into the Head of Protein Sciences, the Associate Director of Protein Analytics will be responsible for building and managing a team of scientists performing analytical characterization of therapeutic drug candidates across a range of different protein modalities. The ideal candidate will have proven track record in performing and managing early and late-stage physiochemical analysis of biologics including monoclonal antibodies, bi/multi-specifics, peptides, and enzymes in a Pharma or Biotech setting.  She/ he will have demonstrated prior hands-on experience with methods such as HPLC/UPLC based methods (SEC, RP, HIC), light scattering (SEC-MALS, DLS), thermal stability (DSF, DSC), capillary electrophoresis-based methods (CE-SDS, cIEF) and mass spectrometry.  She/he will provide leadership within project teams to facilitate project advancement and data feedback to our machine learning platform. 

Responsibilities:

  • Build and lead team of scientists and research associates performing protein analytics to support project advancement and platform optimization.
  • Manage all analytical characterization activities in group being accountable for planning, prioritization, and execution of characterization requests.
  • Stay scientifically current, and implement new technologies and drive innovation, to enhance capabilities with an emphasis on the machine learning data feedback loop
  • Advise the leadership team on staff and resource needs, organizational planning, technology development, and other aspects as Generate continues to grow.
  • Manage external CRO relationships
  • Contribute to Process Development and CMC activities at Generate, interfacing with internal PD/CMC team and CDMOs
  • Potential for project leadership opportunities

Leadership: 

  • Demonstrated ability to work across functions, regions, and cultures
  • Functional level leadership with the ability to inspire, motivate and drive results
  • Embraces and demonstrates a diversity and inclusion mindset and role models these behaviors for the organization
  • Invests time in helping others to enhance their skills and perform at a higher level, including the skill and career development of direct reports

Required Skills/Experience:

  • PhD or MS in science-related discipline
  • Minimum of 8 years PhD/ 12yrs MS of biologics characterization/ protein analytics experience in a biotech/pharma setting
  • Evidence of creativity in addressing difficult protein analytics challenges
  • 5+ years of management experience 
  • Track record of successful leadership, management, and development of multi-disciplinary teams. Strong judge of talent with the ability to make tough talent decisions.
  • Excellent communication, attention to detail, documentation and technical writing skills
  • Familiarity of regulatory issues pertaining to the manufacture of biologics
Location: 
  • Cambridge, MA / Andover, MA
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
 
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.