About Inzen:   

Inzen Therapeutics is a privately held, early-stage biotechnology company exploring ThanokineTM Biology as a surprising and vital driver of disease.  While the ability of living cells to respond to messages from other living cells is a well-established concept, Inzen has identified that living cells also respond to messages released by cells as they undergo turnover and die. We call these messages ThanokinesTM, and the way a cell undergoes turnover dramatically alters the ThanokinesTM that are released. ThanokinesTM can elicit a broad array of responses in living cells, and we have demonstrated that ThanokinesTM plays a previously unrecognized role in the pathogenesis of many important diseases. Our mission is to pioneer a novel category of drugs based on manipulating ThanokineTM Biology to treat cancer, immune and fibrotic diseases, and regenerative processes. 

Inzen Therapeutics was founded by Flagship Pioneering, an organization dedicated to the origination and development of first-in-category life sciences companies.  Since 2000, Flagship has originated and fostered the development of nearly 100 scientific ventures resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.  

The Position:  

Due to the expansion of our R&D capabilities, we are currently on the hunt for a skilled Principal Scientist, Translational Research for our Immuno-Oncology translational research team, where you will be focused on translating new targets and first-in-class drugs.

As a Principal Scientist, you will lead translational research programs primarily supporting cancer immunotherapy programs, using cell and gene therapy approaches. The ideal candidate will have deep scientific experience in Oncology, with an emphasis on Immuno-Oncology. You will have a working knowledge of clinical development and experience developing PD models and mechanism of action studies to support the translation of Inzen’s first programs into the clinic. 

Inzen Therapeutics offers the challenge and opportunity to work at an early-stage, big concept biotechnology company. You will be driving critical programs important to Inzen’s goals. You will contribute to strategic decision-making and initiatives that will give hope to underserved patient populations one day.  

Crucial Responsibilities:  

• Contribute to building a translational immuno-Oncology, supporting small molecules, biologics, cell, and gene therapy programs. 
• Develop innovative preclinical animal models that enable interrogation of mechanisms of action, diagnostic hypotheses, and resistance mechanisms and define PK/PD/efficacy relationships. Oversee MoA studies both internally and at CROs. 
• Provide scientific input and biomarker expertise for early oncology and immune-oncology programs. Work with leadership to develop and operationalize biomarker strategies for the programs. 
• Manage translational efforts across teams in a highly matrixed organization, ensuring rapid execution and open communication 
• Contribute to writing documents to support regulatory filings, patent applications, and manuscripts published in peer-reviewed journals. 

As a Strong candidate, you will possess:  

• Ph.D. degree with 5-8 years’ industry experience, or BS or MS degree with 12 years relevant industry experience in Oncology/Immuno-oncology. 
• Working knowledge of other functional areas of drug development, including toxicology and path to clinical development, is required.
• Experience working with oncolytic viruses is preferred.  
• Hands-on experience in designing, executing, and generating clinic-ready translational biomarker assays in oncology is a plus. 
• Deep understanding of the role of translational research/medicine and clinical biomarkers in drug development. 
• Demonstrated mechanistic understanding of disease biology in oncology and immuno-oncology in the context of drug development (cell and gene therapy preferred, familiarity with small molecule and other biologics a plus). 
• Excellent communication skills across all levels within an organization and external. 
• Demonstrated ability to lead and influence others in a highly matrixed work environment. 
• Comfortable working in a fast-paced environment where speed is paramount.

Inzen Therapeutics and Flagship Pioneering are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or veteran status.