About Alltrna

Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit www.alltrna.com.

About The Role

We are looking for a candidate who is creative, scientifically bold, independent, goal-oriented, has excellent communication skills, is motivated to learn new skills and works collaboratively in a fast-paced entrepreneurial environment.

The ideal candidate has a Ph.D. in molecular biology (or equivalent), an additional 3+ years of relevant experience, and a proven track-record of scientific excellence as evidenced by a strong publication and/or patent record. The candidate has a strong background in molecular and RNA biology with experience designing, performing and analyzing a wide array of cell & molecular biology assays and a demonstrated ability to generate innovative hypotheses in unexplored biological fields. The candidate’s career goals, technical skills, and core competencies should be aligned with the description below.

Core Responsibilities

1. Apply your scientific knowledge, critical thinking skills and creativity to generate and test hypotheses for novel applications of our platform in emerging fields of RNA biology.
2. Design, execute, and interpret multiple experimental workflows with an emphasis on RNA-centric molecular and cellular techniques to test innovation team hypotheses.
3. Thrive on rapid prototyping, strategic triage of ideas, and quickly translating new approaches in the literature into broadly impactful company assets.
4. Develop and apply novel high-throughput methodologies to analyze nucleic acids, protein expression, and cell phenotypes (such as NGS-based methods)
5. Recognize, integrate, and extend next-generation sequencing approaches to screen and address biological hypotheses.
6. Continually cultivate scientific & technical expertise through critical review of the scientific literature, attending external conferences, and developing relationships with key opinion leaders.
7. Work collaboratively with a cross-functional biology, technology, and chemistry team to contribute to the vision, strategy, and tactics of the organization.

Qualifications and Skills

1. Very strong molecular and RNA biology background with extensive hands-on experience in cell-based and molecular biology assays
2. Proven track record in novel RNA-centric method development or application, such as RNA-centric NGS methods (i.e. RNA-seq, Ribo-seq, eCLIP, scRNA-seq)
3. Excellence in experimental design, execution and interpretation
4. Demonstrated ability to approach complex problems with innovative solutions and generate actionable hypotheses
5. Experience in high-throughput cell phenotype screening or other massively parallel assay formats
6. Working knowledge in relevant statistical and bioinformatics methods to enable effective collaboration with computation biology team
7. Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
8. Strong collaborative skills with evidence of working in, and leading a team

The preferred candidate will ideally also possess the following skills:

1. Knowledgeable across a breadth of scientific fields and experience with a broad range of methodologies, such as structure-function relationships in RNA or RNP complexes, or innovative RNA methodologies, e.g. Ribo-seq, RIP-seq, RNA chemical probing.
2. Deep understanding of transcription, translation, and cell signaling
3. Understanding of and experience in proteomics and protein mass spectrometry.