Principal Scientist/Associate Director, Medicinal Chemistry
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Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.
Responsibilities
- Lead research project teams with scientific excellence and urgency to enable progression of research compounds into the clinic. Build well-connected teams that are focused towards solving key research problems and have the ability to create innovative and thoughtful risk-taking approaches if needed. Progress research projects by blending literature research with hands-on laboratory experimentation. Utilize outsourcing budget to maximize impact on research goal achievement.
- Manage the development of scalable routes for potential development compounds that can be easily transitioned to a process chemistry group.
- Partner with research leaders to develop a robust small molecule portfolio that is aligned with Cytokinetics strategic vision.
- Collaborate closely with all functional area leaders in research to ensure efficient workflows and to maintain a diverse and inclusive work environment
- Mentor and support the career development of colleagues within the medicinal chemistry group
- In collaboration with EH&S, oversee and enforce safe working practices within the medicinal chemistry lab.
- External communication of Cytokinetics research through publications and presentations
Qualifications
- Doctorate level degree in relevant area of chemistry, or equivalent industrial experience with 10+ years of relevant experience developing small molecule drugs within the pharmaceutical industry
- Prior experience in Targeted Protein Degradation is strongly desired.
- High level of synthetic chemistry expertise and working knowledge of the important considerations for process development and manufacturing
- Strong record of high impact contributions to research projects that enable progression into the clinic.
- Minimum 5+ experience managing and developing scientists.
- Good understanding of the concepts that drive decision making within all key research and development technical areas that are responsible for drug discovery and development
- Experience collaborating with and leading teams of internal/CRO staff scientists to meet project goals.
- Strong record of peer-reviewed scientific publications and presentation.
- Highly organized with excellent verbal and written communication skills
Actual salary at the time of hire may vary and may be above or below the range based on various factors, including, but not limited to, the candidate’s relevant qualifications, skills, and experience, as well as the service line and location where this position may be filled.
Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.
Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.
Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.
Please visit our website at: www.cytokinetics.com
Cytokinetics is an Equal Opportunity Employer