Company Summary:

Ampersand Biomedicines is an innovative, privately held biotechnology company leading the way in developing multi-specific medicines that direct a wide range of therapeutic molecules to specific cells and biological contexts (www.Ampersand.bio).  Ampersand was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created.  With a strong emphasis on innovation, Ampersand cultivates a highly dynamic and entrepreneurial environment. 

Ampersand Biomedicines‘ Pilsen Team, formerly Abcheck and now a Flagship Pioneering Company, discovers and optimizes human therapeutic antibodies with one of the industry’s most versatile technology platforms. Tailored to specific needs and desired Target Product Profiles, the experienced team leverages both cutting-edge (e.g., microfluidics, rabbit mass humanization) and state-of-the-art (e.g., phage display libraries) technologies to provide high quality leads against a range of diverse targets.

Position Summary:

As an Engineer you will be responsible for development, construction and maintenance of diverse set of microfluidics devices ranging from droplet generator systems to droplet sorter. Your role will be to support antibody discovery for internal campaigns and external customers. You will work in tight collaboration with Antibody discovery team to provide hardware to facilitate discovery projects. The successful candidate will have relevant experience in various engineering fields (e.g., microfabrication, electronics, optics, microfluidics, programming) gained at academia or industry and ability to learn and develop novel approaches and applications. Training in specialized microfluidics techniques will be performed both at AbCheck in Pilsen and at Ampersand in Boston.

This role will be based in Plzen, Czech Republic.

Responsibilities:

• Support technology transfer including novel systems for droplet generation and sorting.
• Building droplet generation and sorting stations together with other engineers from company environment.
• Optimization of microfluidics systems for various applications (mechanical, optical, electrical and electronical optimizations).
• Maintenance of microfluidics systems.
• Fabrication of microfluidic devices using techniques such as soft lithography.

Minimum Qualifications:

• Master's or Ph.D. degree in Mechanical Engineering, Electrical Engineering, Biomedical Engineering, or related field.
• Strong background in general engineering, device design and optimization.
• Excellent problem-solving skills and ability to troubleshoot complex experimental setups.
• Ability to work across multiple teams and support various technology development.
• Proficiency in English.

Preferred Qualifications:

• Experience with microfluidics, including theoretical principles, device design, and fabrication techniques.
• Experience in designing and building custom optical devices, previous work with lasers and/or with high-speed imaging, good knowledge of FPGA, piezo actuators, high-voltage microelectrodes, good knowledge of fluid dynamics and short-range electromagnetic fields is an asset.
• Proficiency in CAD software for (microfluidic) device design.
• Experience with programming environments for instrument operation (e.g., LabView).
• Hands-on experience with microfabrication techniques such as soft lithography, photolithography, and microfluidic chip bonding.
• Experience with microfluidic device integration with other technologies such as sensors, actuators, and electronics.

What We Will Offer you:

• A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
• Participation in an unprecedented opportunity to significantly impact the quality of life of patients by developing a targeted approach to delivering therapeutic molecules.
• Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.