What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines (PM), a division of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. 

Position Summary:

We are seeking a skilled and motivated leader to drive strategy and provide leadership for the Pioneering Medicines Modeling and Simulation (M&S) function. The qualified candidate will apply knowledge and technical expertise to characterize systems biology, pharmacokinetics, and pharmacodynamics-related aspects facilitating research efforts across a diverse portfolio of diseases and therapeutic approaches. We are looking for individuals who are analytical, goal-oriented, and committed to maintaining the highest scientific and ethical standards. Strong communication skills and comfort working in a dynamic, cross-functional team environment are highly desirable.

This role will be based at our Cambridge, MA location. We have a hybrid model and onsite presence 3 times per week is required.

Key Responsibilities:

• Lead and drive modeling and simulation-based efforts for Pioneering Medicine programs from discovery to early development
• Facilitate early research efforts by building systems biology-based mechanistic disease and therapeutic intervention models.
• Explore the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile.
• Develop and validate preclinical PK/PD/Biomarker/Efficacy models to elucidate quantitative PK/PD relationships.
• -Utilize preclinical ADME, pharmacology, and pharmacodynamic data to develop predictions for human efficacious dose.
• Build and lead research-oriented M&S strategies from target engagement to disease-level quantitative systems pharmacology models.
• Identify opportunities where model-informed drug development can advance the understanding of biology, pharmacological activity, and safety.
• Ensure that supporting infrastructure (software, methods, consulting support, etc.) meets all expectations.
• Engage in strategic communication with Pioneering Medicine leaders, cross-functional leadership, and external stakeholders to facilitate M&S-related governance decisions.
• Develop the Modeling and Simulation function within the Pioneering Medicine team.
• Define, monitor, and manage short-term and long-term budgets.
• Supervise, develop and mentor scientists within and outside of the M&S function.
• Foster a culture of continuous learning and improvement.

Education and Experience:

• Ph.D. with 10+ years of experience in pharmacokinetics, pharmaceutical sciences, or other related disciplines
• Strong background in quantitative and qualitative research methodologies related to systems biology, pharmacokinetics, and PK/PD
• Experience supporting drug discovery programs based on standard therapeutic modalities (small molecules, antibodies, and/or peptides)
• Working knowledge of gene-based therapy approaches (gene regulation, RNA medicine, gene therapy) is desirable
• Basic programming skills (e.g., R, Python)
• Hands-on modeling experience using Phoenix Winnonlin, Gastroplus, and/or similar software packages
• Experience managing direct reports is a plus

About Flagship Pioneering:

Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture.   

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet.   

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.