About Alltrna

Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit www.alltrna.com.

About The Role

Come join a creative and collaborative team of scientists at Alltrna dedicated to leveraging emerging insights in RNA biology to develop a novel class of human therapeutics. In this role you will influence chemistry design by applying state-of-the-art computational chemistry approaches to ultimately find treatments for patients with unmet medical needs. You will also help to build an integrated data science platform that embraces FAIR data principles.

Core Responsibilities:

• Conceive and execute computational chemistry strategy in collaboration with Alltrna leadership team
• Work collaboratively with a cross-functional biology, technology, and chemistry team to extend and automate the computational chemistry platform for rapid drug discovery
• Build predictive models including QSAR and ML to drive efficiency and inform drug molecule design
• Develop tools that support medicinal scientists in the representation and design of RNA drug molecules
• Create molecular models of RNA and RNA/protein complexes and use these to enable insights into structural and biological properties
• Create compelling data visualizations for critical internal and investor presentations
• Develop, build, populate, and maintain platform-related databases and tools to query the information
• Be a strong and vocal advocate for data quality and operation within FAIR data principles across the company
• Help to build a world-class computational sciences team at Alltrna

Qualifications and Skills:

• MS or Ph.D. degree in a scientific field coupled with relevant computational chemistry experience, including at least 3+ years in an industrial setting
• Strong programming and statistical analysis skills; proficiency in Python, SQL and R
• Capable of employing quantum chemistry software to model the interfaces between nucleic acids and proteins
• Deep understanding of data-driven algorithmic approaches to molecular design (QSAR/ML/AI)
• Expertise in the use of molecular visualization systems (such as Chimera, PyMol, MOE) and databases
• Skilled in clear and concise written communication
• Adept in creating and giving effective and stimulating presentations
• Ability to present concepts and data to varied audiences that help drive decision-making
• Excellent organizational skills, effective project leader

What We’ll Offer You:

• Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
• A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
• Participation in an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
• Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.
• Daily on-site snacks, cold brew coffee, and Bevi, as well as weekly catered lunches.

Our Core Values:

Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.

Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.

Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and independently achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw insightful conclusions.

Creativity & Innovation. Generates new and creative approaches to problem solving. Positive ‘can-do’ attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation.

Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concisely convey ideas and opinions.

Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities. Is comfortable ‘wearing multiple hats’.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.