The Company:

Generate Biomedicines, Inc. is a Flagship backed, privately-held biotechnology company on a mission to reimagine the drug discovery process to one of deterministic, data-driven generation. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. Generate will be successful by constantly turning innovative ideas into methods, technologies, and therapeutics that solve some of the most difficult challenges with developing medicines. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $180 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology.

The Role:

Generate is seeking a highly creative and technologically curious Senior / Principal Scientist in Quantitative Biology to be part of the growing Platform Innovation Team. The successful candidate will develop, analyze, and optimize truly novel assays at the intersection of synthetic biology, microfluidics, automation, and Machine Learning, enabling high-throughput data generation and interpretation throughout the company. He/she has a proven track record of cross-disciplinary quantitative research, combining deep understanding of biology and high-throughput experimentation with meaningful theoretical/statistical analysis and visualization. The successful candidate will add value throughout the company at various stages of our end-to-end automated data platform, using data from experimental and model-generated sources across protein modalities. Close collaboration with members of Generate’s Protein Science, Computational, and Machine Learning teams will be key to implement solutions to produce game-changing new biological datasets. This is an opportunity to perform highly innovative technology development with considerable intellectual freedom, while being part of the collaborative and premier scientific environment of a well-funded biotech startup.

Responsibilities include, but are not limited to:

• Develop of state-of-the art analytic pipelines for high-throughput assays to study biophysical and biological properties of proteins.
• Propose experimental approaches based on theoretical analysis, statistics, and modeling.
• Work together with members of the Platform Innovation team and other teams to identify opportunities for micro-automation, microfluidics, and microfabricated devices.
• Work closely with the Machine Learning and Computational teams to establish ML-based analysis methodology.
• Present ideas and data, and incorporate feedback, within a cross-functional setting.
• Generate bold, creative, and unconventional ideas, and contribute to intellectual property and patent writing.
• Oversee, mentor, and train junior scientists throughout the company.

Qualifications:

• BSc/MSc with 10+ years of relevant experience or PhD in a relevant science/engineering field (physics, biophysics, physical chemistry, biomedical engineering, or related discipline).
• Demonstrated expertise in implementation, analysis, and optimization of high-throughput biological assays.
• Demonstrated experience in high-throughput library design and NGS-based assay readouts.
• Experience with data analysis in Python, Matlab, R or equivalent.
• Have a solid quantitative mindset and a strong scientific intuition.
• Demonstrated ability to conceive and execute applied biology projects.
• Self-motivated and curious with a desire to learn from and teach others.
• Experience with molecular biology and/or cell biology is strongly preferred.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.