About Inzen:   

Inzen Therapeutics is a privately held, early-stage biotechnology company exploring ThanokineTM Biology as a surprising and vital driver of disease.  While the ability of living cells to respond to messages from other living cells is a well-established concept, Inzen has identified that living cells also respond to messages released by cells as they undergo turnover and die. We call these messages ThanokinesTM, and the way a cell undergoes turnover dramatically alters the ThanokinesTM that are released. ThanokinesTM can elicit a broad array of responses in living cells, and we have demonstrated that ThanokinesTM plays a previously unrecognized role in the pathogenesis of many important diseases. Our mission is to pioneer a novel category of drugs based on manipulating ThanokineTM Biology to treat cancer, immune and fibrotic diseases, and regenerative processes.  

Inzen Therapeutics was founded by Flagship Pioneering, an organization dedicated to the origination and development of first-in-category life sciences companies.  Since 2000, Flagship has originated and fostered the development of nearly 100 scientific ventures resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.   

The Position:   

Come join an exciting new platform dedicated to deeply characterizing Thanokine biology. We have much to learn about this novel area and will get there rapidly with your expertise in designing and executing high throughput, multiplexed assays. You will be responsible for recommending, developing, validating, and troubleshooting assays that are relevant to our mission. Subsequent execution of these assays at scale will feed into our iterative design-build-test cycle for new therapeutic concepts and ultimately advancing drug candidates. This is an opportunity to make an early impact on therapeutic development across the organization. This position will report to the Head of Platform.

Crucial Responsibilities:  

• Play a key role in developing and integrating new high throughput assay technologies into the Inzen Discovery Platform.
• Develop, and execute robust high to medium throughput disease-relevant cell-based and biochemical assays.
• Optimize screening workflows using automation and analysis pipeline in collaboration with our Data Science group.
• Develop and champion innovative approaches to translating thanokine biology into novel therapeutic targets

As a Strong candidate, you will possess:  

• A degree in biochemistry, biology, molecular biology, chemical biology, bio-engineering, or a related field:
  • Bachelors with 5+ years of relevant industry experience, or,
  • Masters with 2+ years of relevant industry experience, or,
  • A Ph.D. with relevant thesis research experience, including industry PhDs
• Prior experience in developing cell culture and co-culture assay systems is required
• Experience with cellular readouts such as luminescence, cell viability, fluorescence, ELISA, flow cytometry, high content imaging, etc. is required
• Experience with multiplex assay systems such as Luminex is strongly preferred
• Demonstrated expertise in developing immunological phenotypic assays including- phagocytosis/ efferocytosis, T-cell activation, macrophage polarization, antigen presentation, etc.
• Strong analytical and problem-solving skills are a must!
• Familiarity with liquid handlers and lab automation is preferred but not required
• Must have strong attention to detail in a rapidly changing environment 
• Adaptability, resourcefulness, and strong verbal communications skills will be necessary to integrate into this team environment 

Inzen Therapeutics and Flagship Pioneering are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or veteran status.  

 Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.