Company:

Generate Biomedicines, Inc. is a Flagship backed, privately-held biotechnology company on a mission to reimagine the drug discovery process to one of dynamic, data-driven generation. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. Generate will be successful by constantly turning innovative ideas into methods, technologies, and products that solve some of the most difficult challenges with developing medicines. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology.

Position:

The Protein Engineering team is establishing high-throughput screening workflows to both generate internal datasets of sequence-function relationships for Generate’s machine learning models and to optimize lead molecules for therapeutic development. We are seeking a motivated and talented Scientist/Sr Scientist to play a key role in implementing novel screening technologies and executing on pipeline projects to drive progress of Generate’s therapeutic candidates. The successful candidate will work closely with scientists from the Computational Biology, Protein Sciences, and Preclinical Discovery and Development teams to advance scientific programs.

Responsibilities:

• Perform DNA cloning and library construction
• Execute yeast display selections and NGS to characterize libraries of protein variants
• Collaborate with Computational Biology team to analyze and interpret NGS results
• Lead program discovery and optimization efforts, working closely with Protein Sciences and Medicines teams to design and optimize therapeutic candidates with desired biological functions and developability profiles
• Develop additional high-throughput screening technologies

Basic qualifications:

• Ph.D. in biochemistry, biophysics, structural biology, bioengineering, or related field; B.S./M.S. with 8+ years relevant industry experience 
• Expertise in protein engineering techniques such as library design and construction, mutagenesis, phage or yeast display
• Demonstrated ability for platform and technology development
• Knowledge of protein characterization techniques (flow cytometry, ELISA, SPR, BLI)
• Familiarity with structural analysis tools such as PYMOL and basic scripting for data analysis beneficial
• Prior experience with laboratory automation preferred
• Attention to detail, ability to multi-task, and strong communication skills

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.